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British Journal of Anaesthesia, Vol 78, Issue 3 286-289, Copyright © 1997 by The Board of Management and Trustees of the British Journal of Anaesthesia

CLINICAL INVESTIGATIONS

Effect of percutaneous local anaesthetics on pain reduction during pulse dye laser treatment of portwine stains

D. F. McCafferty, A. D. Woolfson, J. Handley and G. Allen
School of Pharmacy, the Queen's University of Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL; Department of Dermatology, Ulster Hospital, Dundonald

We have used EMLA, 4% amethocaine gel and placebo for facial portwine stains, for a period of 1 h, in a double-blind study. After removal of the preparations from the skin surface, each area was treated with six pulses of the laser, each 5 mm in diameter. Any pain noted immediately after treatment was recorded using both visual analogue (VAS) and verbal rating (VRS) scores. Twenty nine patients completed the study and statistical analysis of the results indicated that both EMLA and 4% amethocaine gel were superior to placebo (P < 0.001). However, when EMLA and 4% amethocaine gel were compared, the amethocaine preparation was significantly better (P < 0.05, VAS; P < 0.005 VRS) than EMLA in reducing pain caused by the laser treatment.
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