British Journal of Anaesthesia, Vol 78, Issue 3 279-281, Copyright © 1997 by The Board of Management and Trustees of the British Journal of Anaesthesia
S. Kahraman, K. Kilinc, D. Dal and K. Erdem
We studied 20 adult ASA I patients undergoing elective peripheral surgery
allocated randomly to one of two groups. In the propofol group (n = 9)
anaesthesia was induced with propofol and fentanyl followed by continuous
infusion of propofol. In the control group (n = 11), after induction of
anaesthesia with thiopentone and fentanyl, anaesthesia was maintained with
isoflurane. Concentrations of lipid peroxides in both plasma and muscle
tissue samples were measured as thiobarbituric acid- reacting substances
(TBARS). Plasma TBARS concentrations increased significantly in the control
group at 1, 5, 15, 30 and 45 min after release of the tourniquet to mean
1.83 (SD 0.13), 2.00 (0.12), 2.25 (0.14), 2.30 (0.12) and 2.41 (0.14) mumol
litre-1, respectively, compared with pre-reperfusion values (1.64 (0.14)
mumol litre-1). In the propofol group this was significant only at 30 min
(1.85 (0.03) vs 1.74 (0.04) mumol litre-1). TBARS concentrations of
reperfused muscle tissue were significantly higher than pre-reperfusion
concentrations in the control group (70.30(10.06) vs 52.13 (5.73) nmol/g
wet tissue). We conclude that propofol attenuated
ischaemia-reperfusion-induced lipid peroxidation in the therapeutic doses
used in anaesthesia.
CLINICAL INVESTIGATIONS
Propofol attenuates formation of lipid peroxides in tourniquet-induced ischaemia-reperfusion injury
Department of Anaesthesiology and Reanimation, Hacettepe University, School of Medicine, T-06100 Ankara, Turkey; Department of Biochemistry, Hacettepe University, School of Medicine, T-06100 Ankara, Turkey
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