British Journal of Anaesthesia, Vol 77, Issue 6 758-763, Copyright © 1996 by The Board of Management and Trustees of the British Journal of Anaesthesia
C. S. Goodchild, Z. Guo, A. Musgreave and J. P. Gent
Intrathecal midazolam causes antinociception by combining with spinal cord
benzodiazepine receptors. This effect is reversible with doses of naloxone,
suggesting involvement of spinal kappa or delta but not micrograms opioid
receptors. The antinociceptive effects of intrathecally administered drugs
in the spinal cord were demonstrated by measurements of the electrical
current threshold for avoidance behaviour in rats with chronically
implanted lumbar intrathecal catheters. A comparison was made of
suppression by two opioid selective antagonists (nor- binaltorphimine
(kappa selective) and naltrindole (delta selective)) of spinal
antinociception caused by equipotent doses of opioids selective for
different receptor subtypes (U-50488H (kappa), DSLET and DSBULET (delta),
fentanyl (micrograms)) and the benzodiazepine midazolam. Nor-
binaltorphimine selectively suppressed the effects of U-50488H but not
midazolam or fentanyl. However, the delta selective antagonist,
naltrindole, caused dose-related suppression of antinociception produced by
both delta opioid agonists and midazolam with the same ED50 (0.5 nmol). We
conclude that intrathecal midazolam caused spinally mediated
antinociception in rats by a mechanism involving delta opioid receptor
activation.
LABORATORY INVESTIGATIONS
Antinociception by intrathecal midazolam involves endogenous neurotransmitters acting at spinal cord delta opioid receptors
Department of Anaesthesia, University of Leeds, Leeds; Department of Pharmacology, University of Leeds, Leeds
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  Y. K. Batra, R. Mahajan, S. Kumar, S. Rajeev, and M. Singh Dhillon A Dose-Ranging Study of Intraarticular Midazolam for Pain Relief After Knee Arthroscopy Anesth. Analg., August 1, 2008; 107(2): 669 - 672. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. L. Yaksh and J. W. Allen The Use of Intrathecal Midazolam in Humans: A Case Study of Process Anesth. Analg., June 1, 2004; 98(6): 1536 - 1545. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Nishiyama and K. Hanaoka The Synergistic Interaction Between Midazolam and Clonidine in Spinally-Mediated Analgesia in Two Different Pain Models of Rats Anesth. Analg., October 1, 2001; 93(4): 1025 - 1031. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. F. Cox and M. A. Collins The Effects of Benzodiazepines on Human Opioid Receptor Binding and Function Anesth. Analg., August 1, 2001; 93(2): 354 - 358. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. H. Kim and Y. M. Lee Intrathecal midazolam increases the analgesic effects of spinal blockade with bupivacaine in patients undergoing haemorrhoidectomy Br. J. Anaesth., January 1, 2001; 86(1): 77 - 79. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Taira, K. Nakakimura, M. Matsumoto, and T. Sakabe Spinal and supraspinal midazolam potentiates antinociceptive effects of isoflurane Br. J. Anaesth., December 1, 2000; 85(6): 881 - 886. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Nadeson and C. S. Goodchild Antinociceptive Properties of Propofol: Involvement of Spinal Cord gamma -Aminobutyric AcidA Receptors J. Pharmacol. Exp. Ther., September 1, 1997; 282(3): 1181 - 1186. [Abstract] [Full Text]
|
|