British Journal of Anaesthesia, Vol 77, Issue 5 675-677, Copyright © 1996 by The Board of Management and Trustees of the British Journal of Anaesthesia
I. D. Harley, E. F. Jones, G. Liu, P. R. McCall and P. L. McNicol
Orthotopic liver transplantation (OLT) in patients with end-stage liver
disease is a procedure associated with high cardiac output, low systemic
vascular resistance (SVR), coagulopathy and the potential for significant
blood loss. A feature of hypertrophic obstructive cardiomyopathy (HOCM) is
left ventricular outflow tract obstruction which may be exacerbated by
reduced SVR, reduced filling pressures, tachycardia and positive inotropy.
We report two cases of OLT in patients with HOCM. Our anaesthetic technique
involved the use of halothane and vecuronium and avoidance of drugs causing
tachycardia and positive inotropy. Management was aided by intraoperative
transoesophageal echocardiography which showed that filling pressures
poorly reflected end-diastolic volumes. Volume administration,
vasoconstrictors and avoidance of inotropes and chronotropes reduced the
outflow tract obstruction which was particularly severe in the reperfusion
period.
CASE REPORTS
Orthotopic liver transplantation in two patients with hypertrophic obstructive cardiomyopathy
Department of Anaesthesia and Intensive Care, Austin Hospital, Studley Road, Heidelberg, Victoria 3084, Australia; Department of Cardiology, Austin Hospital, Studley Road, Heidelberg, Victoria 3084, Australia
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