British Journal of Anaesthesia, Vol 77, Issue 3 404-407, Copyright © 1996 by The Board of Management and Trustees of the British Journal of Anaesthesia
D. C. Ray, R. Bomont, A. Mizushima, T. Kugimiya, A. Forbes Howie and G. J. Beckett
To assess the effect of sevoflurane anaesthesia on hepatocellular
integrity, we measured plasma concentrations of glutathione S- transferase
(GST) before anaesthesia and 1, 3, 6 and 24 h after the end of anaesthesia
in 41 healthy, Japanese patients undergoing elective, body surface surgery.
Sevoflurane (approximately 1.0 MAC) was delivered in 50-66% nitrous oxide
in oxygen via a circle system, with a fresh gas flow of 6 litre min-1.
Ventilation was spontaneous in all patients. Mean duration of anaesthesia
was 101 min. Concentrations of GST increased significantly 1 h after the
end of anaesthesia (P = 0.0075), but this was not significantly different
from preoperative concentrations at 3, 6 and 24 h. Three patients developed
a large secondary increase in GST concentrations at 24 h. The increase
observed at 1 h was probably a result of reduced total liver blood flow;
the mechanism for the secondary increase at 24 h is unclear but the
possibility that products of sevoflurane biotransformation are responsible
cannot be excluded.
LABORATORY INVESTIGATIONS
Effect of sevoflurane anaesthesia on plasma concentrations of glutathione S-transferase
Department of Anaesthetics, Royal Infirmary, Lauriston Place, Edinburgh EH3 9YW; Department of Clinical Biochemistry, Royal Infirmary, Lauriston Place, Edinburgh EH3 9YW; Department of Anesthesiology, Juntendo University 2-1-1, Hongo, Bunkyo-ku, Tokyo 113, Japan
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