British Journal of Anaesthesia, Vol 76, Issue 6 835-840, Copyright © 1996 by The Board of Management and Trustees of the British Journal of Anaesthesia
L. Lopez-Olaondo, F. Carrascosa, F. J. Pueyo, P. Monedero, N. Busto and A. Saez
We studied 100 ASA I-II females undergoing general anaesthesia for major
gynaecological surgery, in a prospective, double-blind, placebo-
controlled, randomized study. Patients received one of four regimens for
the prevention of postoperative nausea and vomiting (PONV): ondansetron 4
mg (n = 25), dexamethasone 8 mg (n = 25), ondansetron with dexamethasone (4
mg and 8 mg, respectively, n = 25) or placebo (saline, n = 25) There were
no differences in background factors or factors related to operation and
anaesthesia, morphine consumption, pain or side effects between groups. The
incidence of nausea and emetic episodes in the ondansetron with
dexamethasone group was lower than in the placebo (P < 0.01),
ondansetron (P < 0.05) and dexamethasone (P = 0.057) groups. There were
no differences between ondansetron and dexamethasone, and both were more
effective than placebo (P < 0.05 and P < 0.01, respectively).
Dexamethasone appeared to be preferable in preventing nausea than emetic
episodes. Fewer patients in the ondansetron with dexamethasone group needed
antimetic rescue (P < 0.01 vs placebo and P < 0.05 vs ondansetron).
We conclude that prophylactic administration of combined ondansetron and
dexamethasone is effective in preventing PONV.
CLINICAL INVESTIGATIONS
Combination of ondansetron and dexamethasone in the prophylaxis of postoperative nausea and vomiting
Department of Anaesthesiology and Critical Care, University Clinic, School of Medicine, University of Navarra, Pamplona, Spain
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