British Journal of Anaesthesia, Vol 76, Issue 6 802-805, Copyright © 1996 by The Board of Management and Trustees of the British Journal of Anaesthesia
W. P. Gormley, J. M. Murray, JPH. Fee and S. Bower
Peripheral administration of opioids has been suggested as a means of
improving regional block. We studied 60 patients receiving axillary
brachial plexus anaesthesia, allocated randomly to receive either normal
saline 10 ml or normal saline 10 ml with alfentanil 10 micrograms/kg body
weight through an axillary cannula. All patients received 1.5% lignocaine
at a dose of 7 mg/kg body weight with adrenaline 1 in 200,000. The
incidence of satisfactory block was similar in both groups. Although the
percentage of patients with complete anaesthesia in the median nerve
distribution was greater in the alfentanil group, there was no significant
difference in any other distribution. The time to return of sensation and
motor function was prolonged significantly in the alfentanil group (P <
0.05). After return of normal sensation, there was no significant
difference between groups in postoperative analgesia. In a second part of
the study, there was no significant increase in plasma concentrations of
alfentanil in 10 patients given lignocaine and alfentanil, as outlined
above. These observations suggest that alfentanil may have a peripheral
local anaesthetic action.
CLINICAL INVESTIGATIONS
Effect of the addition of alfentanil to lignocaine during axillary brachial plexus anaesthesia
Department of Anaesthesia, The Ulster Hospital, Dundonald, Belfast BT16 0RH; The Queen's University of Belfast, 97 Lisburn Road, Belfast, Northern Ireland; Department of Anaesthesia, 97 Lisburn Road, Belfast, Northern Ireland; University of Newcastle upon Tyne, Newcastle upon Tyne
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  N. Akerman, S. Saxena, R. Wilson, M. Columb, and G. Lyons Effect of intrathecal diamorphine on block height during spinal anaesthesia for Caesarean section with bupivacaine Br. J. Anaesth., June 1, 2005; 94(6): 843 - 847. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. Reuben and J. P. Reuben Brachial Plexus Anesthesia with Verapamil and/or Morphine Anesth. Analg., August 1, 2000; 91(2): 379 - 383. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Nishikawa, N. Kanaya, M. Nakayama, M. Igarashi, K. Tsunoda, and A. Namiki Fentanyl Improves Analgesia but Prolongs the Onset of Axillary Brachial Plexus Block by Peripheral Mechanism Anesth. Analg., August 1, 2000; 91(2): 384 - 387. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. B. Murphy, C. J. L. McCartney, and V. W. S. Chan Novel Analgesic Adjuncts for Brachial Plexus Block: A Systematic Review Anesth. Analg., May 1, 2000; 90(5): 1122 - 1128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Bouaziz, B. P. Kinirons, D. Macalou, M. Heck, F. Dap, D. Benhamou, and M.-C. Laxenaire Sufentanil Does Not Prolong the Duration of Analgesia in a Mepivacaine Brachial Plexus Block: A Dose Response Study Anesth. Analg., February 1, 2000; 90(2): 383 - 383. [Abstract] [Full Text] [PDF]
|
|