British Journal of Anaesthesia, Vol 76, Issue 5 699-701, Copyright © 1996 by The Board of Management and Trustees of the British Journal of Anaesthesia
O. Nordstrom and R. Sandin
We discontinued temporarily an infusion of propofol for surgical reasons in
20 patients undergoing incontinence surgery. The patients, who had not
received neuromuscular blockers, were allowed to regain consciousness to a
level enabling them to cough on command, open their eyes, and identify and
verbally confirm a randomly assigned digit shown on paper. Thereafter, 5-14
min after discontinuation of the propofol infusion, anaesthesia was
reinstituted. Memory of the request to cough, a standard conversation and
the digit shown was tested 1 h after anaesthesia and on the following day.
Only 35% of patients were able to recall one or more of the stimuli
presented during wakefulness or were even able to recall having been
"awake", and there were very few differences in memory on the day after
surgery compared with 1 h after anaesthesia. In comparison with
corresponding stimuli given before anaesthesia, memory of material learned
during wakefulness was significantly impaired (P < 0.0001). Thus
patients temporarily capable of cognitive action during propofol
anaesthesia may have no subsequent explicit recall of intraoperative
events.
CLINICAL INVESTIGATIONS
Recall during intermittent propofol anaesthesia
Department of Anaesthesia, Lanssjukhuset, S-391 85 Kalmar, Sweden
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