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British Journal of Anaesthesia, Vol 76, Issue 5 629-631, Copyright © 1996 by The Board of Management and Trustees of the British Journal of Anaesthesia

CLINICAL INVESTIGATIONS

Soluble E-cadherin concentrations in patients with systemic inflammatory response syndrome and multiorgan dysfunction syndrome

A. J. Pittard, R. E. Banks, H. F. Galley and N. R. Webster
Department of Anaesthesia, St James's University Hospital Trust, Leeds LS9 7TF; ICRF Institute of Cancer Medicine Research, St James's University Hospital Trust, Leeds LS9 7TF

We have assessed the role of the cell-cell adhesion molecule, E- cadherin, in the pathogenesis of multiorgan failure in 24 intensive care patients with sepsis and varying degrees of organ dysfunction, compared with 21 healthy subjects. Plasma soluble E-cadherin (sE- cadherin) was measured by enzyme immunoassay. The median concentration of sE-cadherin in normal subjects was 3.21 micrograms ml-1 compared with 6.00 micrograms ml-1 in patients with sepsis and organ dysfunction (P = 0.0019). There was no statistically significant difference in concentrations of sE-cadherin in survivors compared with non-survivors. Concentrations of sE-cadherin tended to increase with the severity of organ failure. We conclude that sE-cadherin is increased in inflammation and injury, and may be related to the degree of multiorgan failure after sepsis.
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