British Journal of Anaesthesia, Vol 76, Issue 3 412-414, Copyright © 1996 by The Board of Management and Trustees of the British Journal of Anaesthesia
T. G. Ruttmann, MFM. James and J. F. Viljoen
It has been suggested that haemodilution with saline may increase whole
blood coagulation. This study was conducted in two parts. First, we
investigated the effect of in vitro dilution of blood with saline on whole
blood coagulation as measured by the thrombelastogram (TEG). Blood (4 ml)
was diluted with 0.9% saline 1 ml and coagulation compared with that of an
undiluted control specimen obtained concurrently from the same subject. In
the second part, the study was repeated using a modified gelatin colloidal
solution (Haemaccel) as the diluent. The r time, k time and r + k time were
decreased relative to control in both diluent groups. The alpha angles were
increased compared with control in both groups while maximum amplitude was
unchanged in the Haemaccel diluted group. We conclude that haemodilution
per se increases the coagulability of whole blood in vitro, but that saline
haemodilution has a more marked effect on final clot strength.
CLINICAL INVESTIGATIONS
Haemodilution induces a hypercoagulable state
Department of Anaesthesia, University of Cape Town Medical School, Observatory, Cape 7925, Soth Africa
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