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British Journal of Anaesthesia, Vol 76, Issue 3 401-404, Copyright © 1996 by The Board of Management and Trustees of the British Journal of Anaesthesia

CLINICAL INVESTIGATIONS

Comparison of arterialized venous with arterial blood propofol concentrations during sub-anaesthetic infusions in volunteers

K. R. Johnston, M. D. Vickers and W. W. Mapleson
Department of Anaesthetics and Intensive Care Medicine, University of Wales College of Medicine, Cardiff CF4 4XN

We have compared propofol concentrations in arterial and arterialized venous blood (from the radial artery at the wrist and a vein in the opposite forearm) in five volunteers during a sub-anaesthetic increasing infusion regimen designed to produce pseudo-steady-state arterial concentrations of 0.06, 0.17 and 0.43 micrograms ml-1. As in a previous study, we found no statistically significant difference between sampling sites (P = 0.66). However, changes in the method of arterialization yielded a reduction in the observed variability, with the arterialized venous propofol concentration lying within +/- 23% (95% reference interval) of the corresponding arterial concentration compared with 1 +/- 43%, as reported previously.
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M. A. Frolich, D. M. Dennis, J. A. Shuster, and R. J. Melker
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Br. J. Anaesth., April 1, 2005; 94(4): 434 - 437.
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