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British Journal of Anaesthesia, Vol 76, Issue 3 362-364, Copyright © 1996 by The Board of Management and Trustees of the British Journal of Anaesthesia

CLINICAL INVESTIGATIONS

Recovery after desflurane anaesthesia in the infant: comparison with isoflurane

A. R. Wolf, R. A. Lawson, C. M. Dryden and F. W. Davies
Department of Anaesthesia, Royal Hospital for Sick Children, Yorkhill NHS Trust, Glasgow G3 8SJ

We have studied 20 infants, aged 2.5-8 weeks, undergoing general anaesthesia for pyloromyotomy with either desflurane or isoflurane. Patients were anaesthetized with equivalent 1 MAC values for age and agent. A blinded observer recorded times to breathing, swallowing, movement, extubation and side effects after discontinuation of the agent. Recovery times in the desflurane group were significantly shorter than in the isoflurane group. The times to swallowing, movement and extubation in the desflurane group were 3.89 (SD 2.4) min, 5.33 (4.95) min, 7.5 (4.53) min, respectively, and 8.82 (2.40) min, 10.73 (3.93) min, 13.45 (4.20) in the isoflurane group. In addition, postoperative apnoea was documented in the isoflurane group but not in those infants receiving desflurane. There was no laryngospasm after extubation in either group. We conclude that desflurane possesses useful characteristics for recovery conditions in the infant and may be particularly useful in the ex-premature infant prone to apnoea and ventilatory depression.
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