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British Journal of Anaesthesia, Vol 76, Issue 2 316-318, Copyright © 1996 by The Board of Management and Trustees of the British Journal of Anaesthesia

SHORT COMMUNICATIONS

Effect of ondansetron on nausea and vomiting after middle ear surgery during general anaesthesia

P. Honkavaara
Department of Anaesthesia, Otolaryngological Hospital, University of Helsinki, Haartmaninkatu 4E, FIN-00290 Helsinki, Finland

The efficacy of ondansetron 4 mg and 8 mg was compared with placebo in the reduction of postoperative nausea, retching and vomiting (PONV) after middle ear surgery during general anaesthesia, in 75 patients, in a double-blind and randomized study. Both doses of ondansetron were predictors for a decrease in PONV and the number of doses of rescue antiemetic needed per patient (droperidol: from 0.72 in the placebo group to 0.32 in both the 4-mg and 8-mg groups). No reduction in PONV was observed in patients with a history of motion sickness, whereas in patients without a history of motion sickness, ondansetron reduced both the proportion of patients suffering from PONV from 53% to 20% (P < 0.05) and of those needing droperidol from 53% to 17% (P < 0.05).
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