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British Journal of Anaesthesia, Vol 76, Issue 2 308-309, Copyright © 1996 by The Board of Management and Trustees of the British Journal of Anaesthesia

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Dose of propofol for laryngeal mask airway insertion in children: effect of premedication with midazolam

R. A. Martlew, G. Meakin, R. Wadsworth, A. Sharples and R. D. Baker
University Department of Anaesthesia, Royal Manchester Children's Hospital, Pendlebury, Manchester M27 4HA; Department of Mathematics, University of Salford, Salford M5 4WT

We determined the dose-response curves and effective doses of propofol for insertion of the laryngeal mask airway (LMA) in 50 unpremedicated children and in 60 children premedicated with midazolam, aged 3-12 yr. One of several doses of propofol was administered i.v. over 15 s to groups of 10 children, and conditions for LMA insertion were assessed at 60 s. The dose-response curves were parallel (P = 0.94), but the curve for premedicated children was shifted significantly to the left of that for unpremedicated children and propofol requirements were reduced by one-third (P < 0.0001). The doses required for satisfactory LMA insertion in 50% and 90% of unpremedicated patients (ED50, ED90) (95% confidence interval) were 3.8 (3.4-4.2) mg kg-1 and 5.4 (4.7-6.8) mg kg-1, respectively; those for premedicated patients were 2.6 (2.2- 2.8) mg kg-1 and 3.6 (3.2-4.3) mg kg-1, respectively.
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