British Journal of Anaesthesia, Vol 76, Issue 2 227-234, Copyright © 1996 by The Board of Management and Trustees of the British Journal of Anaesthesia
E. Sellden, R. Branstrom and T. Brundin
Intraoperative infusion of amino acids has been found to stimulate energy
expenditure and thereby prevent anaesthesia-induced hypothermia. Rectal
temperature and respiratory gas exchange were measured in 24 female
patients before and after isoflurane anaesthesia. Sixteen patients had an
amino acid mixture of 240 kJ h-1, infused over 1-2 h before anaesthesia and
eight control patients received saline. We compared the results with data
from six female volunteers treated with amino acids; they were not
premedicated or anaesthetized. In lorazepam premedicated patients, amino
acids increased the pre-anaesthesia temperature by 0.3 degrees C h-1, twice
that observed in the volunteers. At awakening after anaesthesia, energy
expenditure increased to 50-60% above baseline in the amino acid treated
patients, while in the control patients, receiving saline, no increase
occurred, despite vigorous shivering. Amino acid infusion prevented
hypothermia by increasing heat accumulation and causing delayed stimulation
of heat production. The heat accumulation response to amino acid infusion
was increased after premedication with lorazepam.
CLINICAL INVESTIGATIONS
Preoperative infusion of amino acids prevents postoperative hypothermia
Department of Anaesthesiology, Karolinska Hospital, S-171 76 Stockholm, Sweden; Department ofClinical Physiology, Karolinska Hospital, S-171 76 Stockholm, Sweden
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