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British Journal of Anaesthesia, Vol 76, Issue 1 81-84, Copyright © 1996 by The Board of Management and Trustees of the British Journal of Anaesthesia

CLINICAL INVESTIGATIONS

Haemodynamic effects of moderate normovolaemic haemodilution in conscious and anaesthetized patients

P. Biboulet, X. Capdevila, D. Benetreau, P. Aubas, F. d'Athis and J. du Cailar
Department of Anaesthesiology and Intensive Care A, University Hopital, Montpellier, France; Department of Medical Information, University Hospital, Montpellier, France France.

We have assessed the haemodynamic effects of moderate normovolaemic haemodilution in ASA I patients, either conscious or during enflurane- fentanyl anaesthesia (10 patients in each group). Cardiac index (CI), stroke index (SI) and ejection fraction (EF) were measured by transthoracic electrical bioimpedance and, in the anaesthesia group, arterial and central venous blood samples were obtained to assess oxygen delivery (DO2), oxygen consumption (VO2) and oxygen extraction ratio (O2ER). In conscious patients, heart rate (HR) remained unchanged as SI, EF and CI increased. When haemodilution was performed during anaesthesia, CI remained stable in spite of a slight increase in SI, as HR decreased. This produced a reduction in DO2 which was compensated for by an increase in O2ER, allowing maintenance of VO2 without alteration in blood lactate concentration.
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