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British Journal of Anaesthesia, Vol 76, Issue 1 43-48, Copyright © 1996 by The Board of Management and Trustees of the British Journal of Anaesthesia

CLINICAL INVESTIGATIONS

Use of near infrared spectroscopy to estimate cerebral blood flow in conscious and anaesthetized adult subjects

H. Owen-Reece, C. E. Elwell, W. Harkness, J. Goldstone, D. T. Delpy, J. S. Wyatt and M. Smith
Department of Anaesthesia, UCL Hospitals, Middlesex Hospital, Mortimer Street, London WC1N 8AA; Department of Medical Physics and Bioengineering University College London, Shropshire House, Capper Street, London WC1E 6JA; Department of Neurological Surgery, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG; Department of Anaesthesia, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG; Department of Paediatrics, University College London Medical School, Rayne Institute, University Street, London WC1E 6JJ

Near infrared spectroscopy (NIRS) can be used to quantify cerebral haemodynamic states non-invasively and to estimate cerebral blood flow (CBF). In the first part of this study we have compared CBF measurements in conscious and anaesthetized subjects. In the second part we have compared paired measurements made during anaesthesia, first on the scalp and then the dura after craniotomy. Mean CBF was 17 (SD 7) ml 100 g-1 min-1 in the conscious subjects compared with 21 (8) ml 100 g-1 min-1 on the scalp during anaesthesia (P > 0.1). Mean CBF on the dura was 68 (21) ml 100 g-1 min-1 (P < 0.0001). Computer modelling suggests that the difference in magnitude between scalp and dura measurements of CBF is likely to be caused by the optical effect of extracerebral tissue which powerfully scatters light passing through it but does not contribute significantly to the measured CBF because it has only a small blood content itself. The results lend support to this method of estimating CBF although formal validation by comparison with an established technique is needed.
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