British Journal of Anaesthesia, Vol 76, Issue 1 29-33, Copyright © 1996 by The Board of Management and Trustees of the British Journal of Anaesthesia
E. P. McCoy, R. K. Mirakhur, V. R. Maddineni, JMKH. Wierda and J. H. Proost
We have studied the pharmacokinetics of a single bolus of rocuronium (Org
9426), followed by an infusion, in eight patients during anaesthesia with
halothane and nitrous oxide in oxygen. Neuromuscular block was monitored
using train-of-four (TOF) stimulation and recording the force of
contraction of the adductor pollicis muscle. Rocuronium was administered as
an initial bolus dose of 0.45 mg kg-1 followed by an infusion adjusted
manually to maintain T1 (first response in the TOF) at 10% of control. Mean
onset time and time to recovery of T1 to 10% were 72 (SD 19.6) s and 27
(9.6) min, respectively. The infusion rates were stable in 19.8 (6.5) min.
The mean requirement for rocuronium for steady state 90% block of T1 was
528 (163.3) micrograms kg-1 h-1. After cessation of surgery the infusion
was stopped and patients were allowed to recover spontaneously. The times
to attain a T1 of 90% and a TOF ratio of 0.7 were 31 (11.7) min and 36
(7.3) min, respectively. Blood samples were collected for 390 min after
cessation of infusion and concentrations of rocuronium and its putative
metabolites measured using HPLC. A two-exponential equation was used to
describe the pharmacokinetic data. The rate of clearance, mean residence
time and volume of distribution at steady state were 3.3 (0.77) ml kg-1
min-1, 67.2 (18.8) min and 212.5 (40.1) ml kg-1, respectively. The
distribution (T1/2 alpha) and elimination (T1/2 beta) half-lives were 7.5
(3.33) min and 85.6 (18.4) min, respectively. These values were not
significantly different from previously published data for a single bolus
dose of rocuronium.
CLINICAL INVESTIGATIONS
Pharmacokinetics of rocuronium after bolus and continuous infusion during halothane anaesthesia
Department of Anaesthetics, The Queen's University of Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland; Research Group for Experimental Anaesthesiology and Clinical Pharmacology, University Hospital, Groningen, The Netherlands
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