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British Journal of Anaesthesia, Vol 76, Issue 1 106-110, Copyright © 1996 by The Board of Management and Trustees of the British Journal of Anaesthesia

LABORATORY INVESTIGATIONS

Effects of morphine on atrial preparations obtained from non-failing and failing human hearts

F. Llobel and M. L. Laorden
Department of Anaesthesiology, CSV Arrixaca Hospital, Murcia, Spain; Department of Physiology and Pharmacology, Unit of Pharmacology, Univesity School of Medicine,CSV Arrixaca Hospital, Murcia, Spain

We have examined the effects of morphine in auricular myocardium from non-failing and failing human hearts. In both preparations morphine induced inhibition. These responses were not antagonized by naloxone. Comparison of mean IC30 values obtained in non-failing (3.9 (SEM 0.2) x 10(-8) mol litre-1) and failing (5010 (200) x 10(-8) mol litre-1) hearts indicated that the morphine concentration-response curves were significantly (P < 0.001) shifted to the right in preparations from failing hearts. In addition, a decrease in the maximal response was observed. These data indicate that opioid receptors are not involved in the cardiac effects induced by morphine and that there is a decrease in responses to morphine in the failing heart.
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