British Journal of Anaesthesia, Vol 75, Issue 5 636-638, Copyright © 1995 by The Board of Management and Trustees of the British Journal of Anaesthesia
K. Ishizaki, D. M. Yoon, N. Yoshida, M. Yamazaki, K. Arai and T. Fujita
We have studied the effect of intrathecal administration of N-methyl-D-
aspartate (NMDA) receptor antagonists on the minimum alveolar anaesthetic
concentration (MAC) of isoflurane in rats. In Wistar rats fitted with
indwelling intrathecal catheters, we determined the MAC of isoflurane after
administration of a competitive NMDA receptor antagonist, APV (0.01, 0.1,
1.0, 10, 30 micrograms), a non-competitive NMDA receptor antagonist, MK801
(0.1, 1.0, 10, 30 micrograms). NMDA (0.01, 0.1, 1.0, 10, 30 micrograms) and
saline. APV at all doses except 0.01 micrograms decreased MAC by 17.1-32%
(P < 0.001 and P < 0.0001). Although MK801 at 10 and 30 micrograms
reduced MAC by 24.3-31.7% (P < 0.001 and P < 0.0001), lower doses did
not affect MAC. Intrathecal administration of NMDA reversed these decreases
in MAC, but not to control values with APV 10 and 30 micrograms and MK801
30 micrograms. We suspect that NMDA and NMDA receptor antagonists play
important roles in the spinal cord in determining the MAC of isoflurane.
SHORT COMMUNICATIONS
Intrathecal administration of N-methyl-D-aspartate receptor antagonist reduces the minimum alveolar anaesthetic concentration of isoflurane in rats
Department of Anesthesiology and Reanimatology, School of Medicine, Gunma University, 3-39-22 Shouwamathi, Maebashi 371, Japan
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