British Journal of Anaesthesia, Vol 75, Issue 5 588-592, Copyright © 1995 by The Board of Management and Trustees of the British Journal of Anaesthesia
M. Naguib, A. H. Samarkandi, H. S. Bakhamees, M. A. Magboul and A. K. El-Bakry
We have examined the effects of different benzyl-isoquinolinium and
steroidal neuromuscular blocking compounds on plasma concentrations of
histamine, heart rate and arterial pressure in surgical patients. A single,
rapid (5-s) bolus of mivacurium 0.2 mg kg-1, atracurium 0.6 mg kg-1,
tubocurarine 0.5 mg kg-1, vecuronium 0.1 mg kg-1 or rocuronium 0.6 mg kg-1
was administered to 75 patients (n = 15 in each group). Anaesthesia was
induced with thiopentone 6 mg kg-1 i.v. and maintained with isoflurane and
70% nitrous oxide in oxygen. Venous blood samples were obtained before
induction, 1 min after thiopentone and 1, 3 and 5 min after administration
of the neuromuscular blocking drug. Mivacurium, atracurium and tubocurarine
caused 370%, 234% and 252% increases in plasma histamine concentrations at
1 min, respectively. Corresponding values at 3 min were 223%, 148% and
157%, respectively. These changes were significant (P < 0.01) at 1 and 3
min. In contrast, the rocuronium and vecuronium groups had no significant
changes in either plasma histamine concentrations or haemodynamic
variables.
CLINICAL INVESTIGATIONS
Histamine-release haemodynamic changes produced by rocuronium, vecuronium, mivacurium, atracurium and tubocurarine
Department of Anaesthesia, King Saud University, Faculty of Medicine at King Khalid University Hospital, PO Box 7805, Riyadh 11472, Saudi Arabia; Department of Surgery, King Saud University, Faculty of Medicine at King Khalid University Hospital, PO Box 7805, Riyadh 11472, Saudi Arabia
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