British Journal of Anaesthesia, Vol 75, Issue 4 457-461, Copyright © 1995 by The Board of Management and Trustees of the British Journal of Anaesthesia
K. Kamitani, M. Yamazaki, M. Yukitaka, Y. Ito and Y. Momose
We have investigated the effect of propofol on isolated rabbit mesenteric
arteries and veins. Isometric tension was measured in rings of arteries
(with or without endothelium) or veins in organ chambers. The preparation
was stimulated with noradrenaline 10(-6) mol litre-1, K+ 50 mmol litre-1
and caffeine 20 mmol litre-1 in the presence or absence of propofol.
Propofol potentiated noradrenaline-induced contractions at lower
concentrations (3 x 10(-5) mol litre-1) and attenuated them at greater
concentrations (10(-4) and 3 x 10(-4) mol litre-1) in arteries with
endothelium. Propofol inhibited noradrenaline- induced contractions in
arteries without endothelium. In contrast, propofol produced venodilatation
in a concentration-dependent manner (10(-5) to 3 x 10(-4) mol litre-1) of
significantly greater magnitude than that in arteries. Propofol inhibited
K+-induced contraction of both arteries and veins. It decreased the
relaxation induced by acetylcholine (3 x 10(-8), 10(-7) and 3 x 10(-7) mol
litre-1) of noradrenaline-induced contractions of arteries. Propofol did
not affect caffeine-induced contractions after pretreatment with increased
Ca2+. We conclude that propofol has a more potent vasodilator effect on
veins than on arteries. Vasoconstriction induced by propofol may be
associated with inhibition of endothelium-derived relaxing factor, whereas
vasodilatation induced by propofol may be associated with block of
voltage-gated influxes of extracellular Ca2+.
LABORATORY INVESTIGATIONS
Effects of propofol on isolated rabbit mesenteric arteries and veins
Department of Anaesthesiology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-01, Japan; Department of Pharmacology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-01, Japan
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