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British Journal of Anaesthesia, Vol 75, Issue 3 352-354, Copyright © 1995 by The Board of Management and Trustees of the British Journal of Anaesthesia

SHORT COMMUNICATION

Effects of intraoperative N-acetylcysteine in orthotopic liver transplantation

P. N. Bromley, S. J. Cottam, I. Hilmi, K. C. Tan, N. Heaton, R. Ginsburg and D. R. Potter
Department of Anaesthesia for Liver Transplantation, King's College Hospital, London SE5 9RS; Department of Surgery for Liver Transplantation King's College Hospital, London SE5 9RS

N-acetylcysteine (NAC) is an antioxidant agent which has been shown to benefit patients with fulminant hepatic failure. We have examined its effect in patients with chronic liver disease undergoing orthotopic liver transplantation by giving NAC during operation. In a prospective, randomized, double-blind, placebo-controlled study of 50 patients, NAC appeared to induce mild vasodilatation, improve oxygen delivery and consumption, and reduce base deficit, but data interpretation was difficult. There were no significant effects on mortality, morbidity or postoperative graft function.
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