Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (10)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Gedney, J. A.
Right arrow Articles by Ghosh, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gedney, J. A.
Right arrow Articles by Ghosh, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, Vol 75, Issue 3 344-351, Copyright © 1995 by The Board of Management and Trustees of the British Journal of Anaesthesia

REVIEW ARTICLE

Pharmacokinetics of analgesics, sedatives and anaesthetic agents during cardiopulmonary bypass

J. A. Gedney and S. Ghosh
Department of Anaesthesia, Addenbrooke's Hospital, Cambridge CB2 2QQ; Department of Anaesthesia, Papworth Hospital, Cambridge CB3 8RE

CPB produces changes in the blood-gas partition coefficient dependent on the prime used and temperature. Fortunately, the overall effect for hypothermic CPB and a crystalloid prime is only +2%. A volatile agent started during hypothermic CPB takes longer to equilibrate and agents already in use need to re-equilibrate, potentially changing the depth of anaesthesia, until equilibration is complete. As these agents are metabolized to a small degree and washout is fast, the duration of action is not prolonged after CPB.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
P. J. Davis, A. S. Wilson, R. D. Siewers, F. A. Pigula, and I. S. Landsman
The Effects of Cardiopulmonary Bypass on Remifentanil Kinetics in Children Undergoing Atrial Septal Defect Repair
Anesth. Analg., October 1, 1999; 89(4): 904 - 904.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
D. J. Cook
Changing Temperature Management for Cardiopulmonary Bypass
Anesth. Analg., June 1, 1999; 88(6): 1254 - 1254.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.