Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (5)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Igarashi, M.
Right arrow Articles by Iwasaki, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Igarashi, M.
Right arrow Articles by Iwasaki, H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, Vol 75, Issue 3 339-343, Copyright © 1995 by The Board of Management and Trustees of the British Journal of Anaesthesia

LABORATORY INVESTIGATIONS

Mechanism of the differential sensitivity in the rat adductor and abductor laryngeal muscles to a non-depolarizing neuromuscular blocker

M. Igarashi and H. Iwasaki
Department of Anesthesiology, Sapporo Medical University School of Medicine, South-1, West-16, Chuoku, Sapporo 060, Japan

We have compared the neuromuscular blocking effects of tubocurarine at pre- and postsynaptic sites in the lateral cricoarytenoid muscle (LCA) (one of the adductor muscles of the vocal cords) and in the posterior cricoarytenoid muscle (PCA) (sole abductor muscle of the vocal cords) of the rat. Fine wire electrodes were inserted into both muscles and evoked compound electromyographic (EMG) responses measured by supramaximal stimulation of the recurrent laryngeal nerves. End-plate potentials (EPP), mean quantal content and carbachol sensitivity to tubocurarine in both muscles were measured using intracellular microelectrodes. Tubocurarine produced a concentration-dependent reduction in the EMG responses, EPP amplitude, mean quantal content and carbachol sensitivity. The LCA muscle was more resistant to tubocurarine than the PCA muscle in EPP amplitude, mean quantal content and carbachol sensitivity, suggesting unequal pre- and postsynaptic sensitivity for inhibition of elicited acetylcholine release, reduction in EPP amplitude and loss of evoked muscle action potentials. Examination of muscle fibre composition demonstrated that the LCA muscle contained a significantly higher fraction of slow twitch muscle fibres than PCA muscle. However, the sizes of the fibres were similar in both muscles. We conclude that the mechanism of unequal sensitivity to a non-depolarizing neuromuscular blocker in the LCA and PCA muscles may be explained by differential sensitivities at the pre- and postsynaptic sites of the neuromuscular junction.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
A. Michalek-Sauberer, H. Gilly, T. M. Hemmerling, G. Michaud, S. Deschamps, and G. Trager
Neuromuscular Blockade at Laryngeal Muscles * Response
Anesth. Analg., January 1, 2005; 100(1): 297 - 298.
[Full Text] [PDF]

Home page
 Anesth. Analg.Home page
T. M. Hemmerling, G. Michaud, G. Trager, and F. Donati
Simultaneous Determination of Neuromuscular Blockade at the Adducting and Abducting Laryngeal Muscles Using Phonomyography
Anesth. Analg., June 1, 2004; 98(6): 1729 - 1733.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.