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British Journal of Anaesthesia, Vol 75, Issue 3 311-318, Copyright © 1995 by The Board of Management and Trustees of the British Journal of Anaesthesia

LABORATORY INVESTIGATIONS

Biodistribution of liposomes after extradural administration in rodents

V. Umbrain, M. Alafandy, P. Bourgeois, J. D'Haese, J. G. Boogaerts, G. Goffinet, F. Camu and F. J. Legros
Department of Anaesthesiology, Flemish Free University of Brussels Clinical Centre, 101, Laarbeeklaan, 1090 Brussels, Belgium; Department of Isotopes, J. Bracops Hospital, Brussels, Belgium; Laboratory of General Biology and Ultrastructural Morphology, University of Liege, Liege, Belgium; Department of Anaesthesiology, City Hospital, Charleroi, Belgium

We have mapped over 24 h the biodistribution of 99mTc-labelled multilamellar and small unilamellar liposomes in rabbits and rats by scintigraphic imaging after extradural injection. Multilamellar vesicles formed a depot at the site of injection; small unilamellar vesicles spread immediately along the extradural space and entered the systemic compartment 30 min after injection. Well-delineated liver and kidney labellings were seen after 24 h. The use of 3H-cholesterol- labelled small unilamellar vesicles suggested hepatic capture of intact liposomes with sizes averaging 0.05 microns drained unmodified into the systemic circulation through the extradural lymphatics. These results have led to the selection of multilamellar vesicles (0.1-15 microns size range) for clinical trials using liposome-associated local anaesthetics.
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