British Journal of Anaesthesia, Vol 75, Issue 3 289-292, Copyright © 1995 by The Board of Management and Trustees of the British Journal of Anaesthesia
P. B. Loan, R. K. Mirakhur, L. D. Paxton and J. H. Gaston
We studied 50 ASA I-II patients, aged 18-65 yr, undergoing elective
orofacial surgery. Anaesthesia was induced with fentanyl and propofol, and
maintained with 66% nitrous oxide in oxygen and either desflurane or
isoflurane to compare recovery characteristics and cardiovascular
stability. Cardiovascular responses to induction, intubation and incision
were similar with both agents, although the increase in heart rate in
response to intubation was less marked in the desflurane group. Maximum
end-tidal concentrations of desflurane required were 4.0-10.6% (mean 6.8%)
compared with maximum isoflurane concentrations of 1.1-2.3% (mean 1.6%).
Mean duration of anaesthesia was 46 (SD 17.9) min (range 25-89 min) in the
desflurane group and 41 (11.5) (23-60) min in the isoflurane group. Times
to extubation were 6.7 (2.1) (3-10) min and 11.3 (4.1) (5-23) min, to eye
opening 6.8 (2.2) (3-11) min and 12.7 (6.9) (7-37) min, to stating date of
birth 9.0 (2.3) (4-12) min and 15.0 (6.9) (8-39) and to discharge from the
recovery room 45 (11.6) (22- 80) min and 64 (20.9) (28-134) min, for the
desflurane and isoflurane groups, respectively (all P < 0.0001). No
serious complications occurred in any patient.
CLINICAL INVESTIGATIONS
Comparison of desflurane and isoflurane in anaesthesia for dental surgery
Department of Anaesthetics, The Queen's University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL; The Royal Victoria Hospital, Belfast
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