British Journal of Anaesthesia, Vol 75, Issue 1 55-60, Copyright © 1995 by The Board of Management and Trustees of the British Journal of Anaesthesia
S. Petersen-Felix, L. Arendt-Nielsen, P. Bak, D. Roth, M. Fischer, P. Bjerring and A. M. Zbinden
The analgesic effect of subanaesthetic concentrations of ether,
trichloroethylene, methoxyflurane and halothane has been investigated
previously using either clinical assessment or pain threshold measurements,
but with conflicting results. The purpose of the present study was to
evaluate the analgesic effect of isoflurane using experimental pain models.
We studied 12 healthy volunteers at three randomly chosen subanaesthetic
isoflurane concentrations: low (0.10- 0.14 vol%), middle (0.16-0.20 vol%)
and high (0.22-0.26 vol%). We used thermal pain detection and pain
tolerance thresholds to argon laser stimulation, pressure pain detection
and pain tolerance thresholds, immersion of the hand in ice water, and the
nociceptive reflex to single and repeated (temporal summation) electrical
stimulations, as experimental models to assess analgesia. There were no
significant changes in the response to heat, cold or mechanical pressure at
any of the subanaesthetic concentrations of isoflurane used. The
nociceptive reflex thresholds to single stimulations, but not the
thresholds for repeated stimulations, were significantly increased in all
three isoflurane groups compared with baseline values. The difference
between the different isoflurane concentrations was not statistically
significant. In experimental pain models, subanaesthetic isoflurane
concentrations have little or no analgesic potency.
CLINICAL INVESTIGATIONS
Analgesic effect in humans of subanaesthetic isoflurane concentrations evaluated by experimentally induced pain
Department of Anaesthesiology and Intensive Care, University Hospital of Bern, Switzerland; Center for Sensory-Motor Interaction, Laboratory for Experimental Pain Reasearch, University of Aalborg, Denmark; Department of Dermatology, University Hospital of Aarhus, Denmark
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