British Journal of Anaesthesia, Vol 75, Issue 1 51-54, Copyright © 1995 by The Board of Management and Trustees of the British Journal of Anaesthesia
K. S. Olsen, L. B. Svendsen, F. S. Larsen and O. B. Paulson
We have studied the effects of labetalol on cerebral blood flow (CBF) and
cerebral oxygen metabolism (CMRO2) in eight healthy volunteers. CBF was
measured by single photon emission computerized tomography before and
during infusion of labetalol. CMRO2 was calculated as CBF x cerebral
arteriovenous oxygen content difference (CaO2-CvO2). CBF autoregulation was
tested during infusion of labetalol by changing arterial pressure and
estimating relative changes in global CBF from changes in (CaO2-CvO2). CBF
before and during infusion of labetalol was 67 and 65 ml/100 g min-1,
respectively (P > 0.05). CMRO2 was 2.9 and 2.8 ml/100 g min-1,
respectively (P > 0.05). CBF autoregulation was preserved in all
subjects. The lower limit of CBF autoregulation was 88 mm Hg (94% of
baseline mean arterial pressure). We conclude that labetalol did not
influence global or regional CBF, or CMRO2, and CBF autoregulation was
preserved.
CLINICAL INVESTIGATIONS
Effect of labetalol on cerebral blood flow, oxygen metabolism and autoregulation in healthy humans
Department of Anaesthesia, Rigshospitalet, Copenhagen, Denmark; Department of Medicine A, Rigshospitalet, Copenhagen, Denmark; Department of Neurology, Rigshospitalet, Copenhagen, Denmark
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