Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by FENG, J.
Right arrow Articles by KENDIG, J. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by FENG, J.
Right arrow Articles by KENDIG, J. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 1995, Vol. 74, No. 6 691-696
© 1995 The Board of Management and Trustees of the British Journal of Anaesthesia

other

Selective effects of alfentanil on nociceptive-related neurotransmission in neonatal rat spinal cord

J. FENG, MD and J. J. KENDIG, PHD

Department of Anesthesia, Stanford University School of Medicine Stanford, CA 94305-5117, USA

correspondence to J.J.K.

We have examined the effects of alfentanil on nociceptive-related neurotransmission in isolated neonatal rat spinal cord, with particular attention to acute tolerance. Electrical stimulation of a lumbar dorsal root was used to evoke the monosynaptic reflex (MSR), a slow ventral root potential (sVRP), and the dorsal root potential (DRP). Alfentanil (0.5 nmol litre–1 to 1 µmol litre–1) depressed sVRP area by a maximum of 85%; EC50 was approximately 2 nmol litre–1. The effects of alfentanil were selective for very slow, metabotropically mediated sVRP components compared with faster NM DA receptor-mediated components. The MSR was unaffected. Alfentanil depressed DRP area by a maximum of 50% at 1 µmol litre–1. Naloxone antagonized all alfentanil effects. Morphine depressed sVRP area with an approximate EC50 of 90 nmol litre–1, giving an alfentanil:morphine potency ratio of 45:1. The effects of alfentanil on sVRP showed no biphasic time dependence up to 60 min. Naloxone administered after alfentanil produced a significant rebound in sVRP area to a level of 143 (SD 21.3)% above control. Thus, in this study there was no evidence for acute tolerance, as measured by a decrease in effectiveness over time, but there was evidence as measured by rebound following naloxone.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Br J AnaesthHome page
J. J. Kendig
In vitro networks: subcortical mechanisms of anaesthetic action
Br. J. Anaesth., July 1, 2002; 89(1): 91 - 101.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
S. M. E. Wong, J. M. Sonner, and J. J. Kendig
Acetylcholine Receptors Do Not Mediate Isoflurane's Actions on Spinal Cord In Vitro
Anesth. Analg., June 1, 2002; 94(6): 1495 - 1499.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
I. Kissin, C. A. Bright, and E. L. Bradley Jr.
Acute Tolerance to Continuously Infused Alfentanil: The Role of Cholecystokinin and N-Methyl-D-Aspartate-Nitric Oxide Systems
Anesth. Analg., July 1, 2000; 91(1): 110 - 116.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
S. M. E. Wong, D. L. Tauck, E. G. Fong, and J. J. Kendig
Glutamate Receptor-Mediated Hyperexcitability after Ethanol Exposure in Isolated Neonatal Rat Spinal Cord
J. Pharmacol. Exp. Ther., April 1, 1998; 285(1): 201 - 207.
[Abstract] [Full Text]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.