Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (45)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by BITO, H.
Right arrow Articles by IKEDA, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by BITO, H.
Right arrow Articles by IKEDA, K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 1995, Vol. 74, No. 6 667-669
© 1995 The Board of Management and Trustees of the British Journal of Anaesthesia

other

Effect of total flow rate on the concentration of degradation products generated by reaction between sevoflurane and soda lime

H. BITO, MD and K. IKEDA, MD

Department of Anaesthesiology and Intensive Care, Hamamatsu University School of Medicine 3600 Handa-cho Hamamatsu 431-31, Japan

We have compared concentrations of degradation products in the circle system during sevoflurane anaesthesia at different fresh gas flows. Twenty-four patients underwent sevoflurane anaesthesia with fresh gas flows of 1 litre min–1 (1L group), 3 litre min–1 (3L group), or 6 litre min–1 (6L group) (n = 8 in each group). During anaesthesia, the concentrations of degradation products were measured every hour, and the temperature of soda lime, end-tidal carbon dioxide concentration, inspired and end-tidal sevoflurane concentrations, and carbon dioxide elimination were measured. CF2=C(CF3)—0—CH2F (compound A) was the only degradation product detected. The mean maximum concentration of compound A was 19.7 (SD 4.3) ppm in the 1 L group, 8.1 (2.7) ppm in the 3L group and 2.1 (1.0) ppm in the 6L group (P > 0.05). The maximum temperature of soda lime was 44.6 (1.5) °C in the 1 L group, 37.0 (4.4) °C in the 3L group and 29.1 (5.1) °C in the 6L group (P > 0.05). There were no significant differences in end-tidal sevoflurane concentration or mean carbon dioxide elimination between the groups. Only compound A was detected following anaesthesia, with higher concentrations observed at lower flow rates.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
E. D. Kharasch, E. J. Frink Jr., A. Artru, P. Michalowski, G. A. Rooke, and W. Nogami
Long-Duration Low-Flow Sevoflurane and Isoflurane Effects on Postoperative Renal and Hepatic Function
Anesth. Analg., December 1, 2001; 93(6): 1511 - 1520.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
R. Obata, H. Bito, M. Ohmura, G. Moriwaki, Y. Ikeuchi, T. Katoh, and S. Sato
The Effects of Prolonged Low-Flow Sevoflurane Anesthesia on Renal and Hepatic Function
Anesth. Analg., October 1, 2000; 91(5): 1262 - 1268.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
H. Higuchi, Y. Adachi, S. Arimura, M. Kanno, and T. Satoh
Compound A Concentrations During Low-Flow Sevoflurane Anesthesia Correlate Directly with the Concentration of Monovalent Bases in Carbon Dioxide Absorbents
Anesth. Analg., August 1, 2000; 91(2): 434 - 439.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
M. Yamakage, S. Yamada, X. Chen, S. Iwasaki, N. Tsujiguchi, and A. Namiki
Carbon Dioxide Absorbents Containing Potassium Hydroxide Produce Much Larger Concentrations of Compound A from Sevoflurane in Clinical Practice
Anesth. Analg., July 1, 2000; 91(1): 220 - 224.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
R. F. Bedford and H. E. Ives
The Renal Safety of Sevoflurane
Anesth. Analg., March 1, 2000; 90(3): 505 - 508.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.