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British Journal of Anaesthesia, 1995, Vol. 74, No. 5 614-615
© 1995 The Board of Management and Trustees of the British Journal of Anaesthesia

other

Lansoprazole in the prophylaxis of acid aspiration during elective surgery

D. A. HETT, FRCA, R. C. SCOTT, FRCA and J. E. RISDALL, FFARCSI

Royal Naval Hospital Haslar Gosport, Hants

Address for correspondence: Anaesthetic Department, Southampton General Hospital, Tremona Road, Southampton SO9 4XY

We have assessed the efficacy of a single dose of lansoprazole in increasing the pH and decreasing the volume of gastric residue at induction of anaesthesia in adult patients undergoing elective orthopaedic surgery. We studied 66 ASAI-II patients, allocated to one of three groups to receive either placebo (group 1), lansoprazole 30 mg (group 2) or lansoprazole 60 mg (group 3), 8–12 h before induction of anaesthesia. Volume and pH of gastric contents were measured after induction of anaesthesia by aspiration via a 16-French gauge gastric tube. Patients who received lansoprazole had a significantly higher pH than the placebo group (P < 0.01) but there was no difference between the two lansoprazole groups. The volume of gastric residue was significantly smaller (P < 0.01) in both lansoprazole groups compared with the placebo group: 28% of those in group 3 had a pH of gastric residue < 2.5 and volume > 25 ml compared with 30% in group 2 and 63% in group 1, respectively. (Br. J. Anaesth. 1995; 74: 614–615)


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