Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (49)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by HIIPPALA, S.
Right arrow Articles by NIEMELÄ, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by HIIPPALA, S.
Right arrow Articles by NIEMELÄ, H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 1995, Vol. 74, No. 5 534-537
© 1995 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

Tranexamic acid (Cyklokapron) reduces perioperative blood loss associated with total knee arthroplasty

S. HIIPPALA, MD, L. STRID, MD, M. WENNERSTRAND, MD, V. ARVELA, MD, S. MÄNTYLÄ, MD, J. YLINEN, MD and H. NIEMELÄ, MD

Department of Anaesthesia, South Carelian Central Hospital Käkelänkaru 1, FIN 53130 Lappeenranta, Finland
Department of Orthopaedic Surgery, South Carelian Central Hospital Käkelänkaru 1, FIN-53130 Lappeenranta, Finland

Correspondence to S. H.

In this prospective, randomized, double-blind study, we have investigated the effect of an antifibrinolytic agent, tranexamic acid (Cyklokapron), on blood loss and transfusion requirements associated with total knee arthroplasty. Twenty-nine patients were allocated randomly to receive either tranexamic acid 15 mg kg–1 or an equal volume of placebo a few minutes before a tourniquet was deflated. Blood loss during surgery, in the recovery room and on the surgical ward was recorded, together with the number of units of blood transfused in hospital. Mean blood loss during surgery was 428 (SD 254) ml in the tranexamic acid group (n = 15) compared with 41 5 (244) ml in the placebo group (n = 13). In the recovery room the tranexamic acid group lost 127 (95) ml and the placebo group 576 (245) ml (P < 0.001). On the ward the respective volumes were 293 (200) ml and 558 (293) ml (P < 0.01). Total blood loss was 847 (356) ml in the tranexamic acid group and 1549 (574) ml in the placebo group (P < 0.001). During the hospital stay the treatment group received 1.5 (1.3) units of blood compared with 3.3 (1.8) in the control group (P < 0.005). Two patients in the placebo group experienced a thrombotic complication compared with none in the treatment group. We conclude that tranexamic acid reduced perioperative blood loss and transfusion requirements associated with total knee arthroplasty. (Br. J. Anaesth. 1995; 74: 534–537)


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J Bone Joint Surg BrHome page
K. Rajesparan, L. C. Biant, M. Ahmad, and R. E. Field
The effect of an intravenous bolus of tranexamic acid on blood loss in total hip replacement
J Bone Joint Surg Br, June 1, 2009; 91-B(6): 776 - 783.
[Abstract] [Full Text] [PDF]

Home page
 J Bone Joint Surg BrHome page
D. O. Molloy, H. A. P. Archbold, L. Ogonda, J. McConway, R. K. Wilson, and D. E. Beverland
Comparison of topical fibrin spray and tranexamic acid on blood loss after total knee replacement: A PROSPECTIVE, RANDOMISED CONTROLLED TRIAL
J Bone Joint Surg Br, March 1, 2007; 89-B(3): 306 - 309.
[Abstract] [Full Text] [PDF]

Home page
 JBJSHome page
S. Yamasaki, K. Masuhara, and T. Fuji
Tranexamic Acid Reduces Postoperative Blood Loss in Cementless Total Hip Arthroplasty
J. Bone Joint Surg. Am., April 1, 2005; 87(4): 766 - 770.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
L. Good, E. Peterson, and B. Lisander
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement
Br. J. Anaesth., May 1, 2003; 90(5): 596 - 599.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
J. M. Engel, T. Hohaus, R. Ruwoldt, T. Menges, I. Jurgensen, and G. Hempelmann
Regional Hemostatic Status and Blood Requirements After Total Knee Arthroplasty With and Without Tranexamic Acid or Aprotinin
Anesth. Analg., March 1, 2001; 92(3): 775 - 780.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
G. Ekback, K. Axelsson, L. Ryttberg, B. Edlund, J. Kjellberg, J. Weckstrom, O. Carlsson, and U. Schott
Tranexamic Acid Reduces Blood Loss in Total Hip Replacement Surgery
Anesth. Analg., October 1, 2000; 91(5): 1124 - 1130.
[Abstract] [Full Text] [PDF]

Home page
 JBJSHome page
O. LEVY, U. MARTINOWITZ, A. ORAN, C. TAUBER, and H. HOROSZOWSKI
The Use of Fibrin Tissue Adhesive to Reduce Blood Loss and the Need for Blood Transfusion After Total Knee Arthroplasty. A Prospective, Randomized, Multicenter Study
J. Bone Joint Surg. Am., November 1, 1999; 81(11): 1580 - 8.
[Abstract] [Full Text]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.