Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by BLOBNER, M.
Right arrow Articles by KOCHS, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by BLOBNER, M.
Right arrow Articles by KOCHS, E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 1995, Vol. 74, No. 4 452-454
© 1995 The Board of Management and Trustees of the British Journal of Anaesthesia

other

Effect of renal function on neuromuscular block induced by continuous infusion of mivacurium

M. BLOBNER, MD, S. JELEN-ESSELBORN, MD, PHD, G. SCHNEIDER, MD, R. MANN, MD, M. KLING, MD, P. LUPPA, MD, H. J. SCHNECK, MD, PHD and E. KOCHS, MD, PHD

Institut für Anaesthesiologie and Institut für Klinische Chemie und Pathobiochemie der Technischen Uni versität München Klinikum rechts der Isar, Ismaninger Straße 22, D-81675 Munich, Germany

We have studied the effect of renal function on the pharmacodynamics of mivacurium. Sixty patients were allocated to three groups according to creatinine clearance: group C(control), creatinine clear ance >50 ml min–1; group P(preterminal renal failure), creatinine clearance < 50 ml min1 > 20 ml min–1; group T(terminal renal failure), creatinine clearance < 20 ml min Neuromuscular transmission (train-of-four) was monitored using electromyography from the hypothenar muscle with stimulation of the ulnar nerve. After an initial bolus, mivacurium was administered continuously to maintain a T1 of 5 (4)% of baseline. The dose of mivacurium necessary to maintain 95% neuromuscular block was similar in patients with normal renal function and patients with different levels of renal impairment. Recovery from neuromuscular block after ceasing mivacurium infusion was significantly prolonged in patients with preterminal renal impairment. There was a close correlation between mivacurium pharmacodynamics and pseudocholinesterase activity, but not creatinine clearance.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.