Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by BOOKER, P. D.
Right arrow Articles by FRANKS, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by BOOKER, P. D.
Right arrow Articles by FRANKS, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 1995, Vol. 74, No. 4 419-423
© 1995 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

Comparison of the haemodynamic effects of dopamine and dobutamine in young children undergoing cardiac surgery

P. D. BOOKER, FRCA, C. EVANS, FRCA* and R. FRANKS, FRCS

Royal Liverpool Children's NHS Trust Eaton Road, Liverpool L12 2AP

Nineteen children, aged 2–54 months, requiring high-dose inotropic support after cardiac surgery, were given either dopamine or dobutamine in a blinded, double crossover, study. Using a pulmonary artery thermistor, right and left atrial cannulae, and pulmonary and femoral arterial catheters, conventional haemodynamic variables were meas ured hourly over three consecutive 4 h dopamine-dobutamine-dopamine or dobutamine-dopamine-dobutamine exchanges. No significant differences in haemodynamics occurred during dopamine therapy compared with the same dose of dobutamine in 14 patients receiving phenoxybenzamine 2mg kg–1 four of whom had also received enoximone. In five patients, neither enoximone nor phenoxy benzamine was used and significant increases in pulmonary artery pressure and pulmonary vascular resistance (P = 0.04) occurred when patients were given dopamine rather than dobutamine. We conclude that dobutamine and dopamine are equipotent inotropes in children and that dopamine in doses > 7 µg kg–1 min–1 caused pulmonary vasoconstriction, an effect mediated by {alpha} adrenergic receptors.

*Present address: University Hospital of Wales, Heath Park, Cardiff


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 ThoraxHome page
P. Egermayer, G I. Town, and A. J Peacock
Role of serotonin in the pathogenesis of acute and chronic pulmonary hypertension
Thorax, February 1, 1999; 54(2): 161 - 168.
[Full Text]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.