Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by GYERMEK, L.
Right arrow Articles by LEE, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by GYERMEK, L.
Right arrow Articles by LEE, C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 1995, Vol. 74, No. 4 410-414
© 1995 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

Antagonism of pancuronium- and pipecuronium-induced neuromuscular block

L. GYERMEK, MD, PHD, E. M. CANTLEY, MA and C. LEE, MD

Department of Anesthesiology, Harbor-UCLA Medical Center 1000 West Carson Street, Torrance, CA 90222, USA

We have compared the antagonism of neuro muscular block produced by pipecuronium with pancuronium in 80 anaesthetized surgical patients using mechanomyography and electromyography. Pancuronium 0.1 mg kg or pipecuronium 0.07 mg kg–1 was given after induction of anaesthesia and neuromuscular block was adjusted to 75% twitch depression at the time of antagonism. The following regimens were used: edrophonium 0.5 and 1.0 mg kg–1, neostigmine 0.04 mg kg–1 pyridostigmine 0.3 mg kg–1 and edrophonium 0.25 mg kg–1 with pyridostigmine 0.15 mg kg–1. Antagonism was evaluated also by the head lift test. There was no difference between the reversibility of neuromuscular block produced by pancuronium or pipecuronium. Edrophonium produced a significantly faster antagonism than neostigmine or pyridostigmine but onset of action was not significantly faster than that of edrophonium with pyridostigmine. All regimens produced 100% (or near 100%) antagonism of twitch response within 15 min. However, TOF fade antagonism was more complete with pyridostigmine, neostigmine and edrophonium 1.0 mg kg–1 than with edrophonium 0.5 mg kg–1. The head lift test indicated somewhat less antagonism with edrophonium 0.5 and 1.0 mg kg–1. Using five monitoring methods, the rank order of reversal potency was: pyridostigmine ~ neostigmine > edrophonium 1.0 mg kg–1 edrophonium + pyridostigmine > edrophonium 0.5 mg kg–1.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.