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British Journal of Anaesthesia, 1995, Vol. 74, No. 3 301-305
© 1995 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

Lack of bronchodilator effect after administration of subanaesthetic concentration of isoflurane in mild asthmatic subjects challenged with methacholine

F. J. MERCIER, MD, D. BENHAMOU, MD and A. DENJEAN, MD, PHD

Départment d'Anesthésie, Hôpital Antoine Béclère, 157 rue de la Porte de Trivaux, 92141 Clamart, France.
Laboratoire d'Explorations Fonctinnelles, Hôpital Antoine Béclère, 157 rue de la Porte de Trivaux, 92141 Clamart, France.

Volatile anaesthetics used in high concentrations are potent bronchodilators. The effect of lower subanaesthetic concentrations is less documented, particularly in humans with provoked bronchial obstruction. We have studied seven mild asthmatic subjects twice, 1 week apart, during an asymptomatic period. A provocative test with methacholine was performed to produce a decrease in forced expiratory volume in 1 s (FEV1) of at least 20%. The subjects then inhaled either 100% oxygen or 0.75% isoflurane in oxygen for 8 min, via a face mask. During isoflurane inhalation, the subjects lost consciousness but recovered quickly. There was no significant improvement in FEV1 and maximum expiratory flow at 50% vital capacity (MEF50) recorded 3, 6, 9, 14 and 19 min after the end of isoflurane inhalation compared with time-control values. We conclude that lung function in mild asthmatic subjects challenged with methacholine was not improved after administration of a low sub-anaesthetic concentration of isoflurane. This may be important during recovery from general anaesthesia. (Br. J. Anaesth. 1995; 74: 301–305)


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