Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (15)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by MATTA, B. F.
Right arrow Articles by STREBEL, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by MATTA, B. F.
Right arrow Articles by STREBEL, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 1995, Vol. 74, No. 3 296-300
© 1995 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

Cerebrovascular response to carbon dioxide during sodium nitroprusside- and isoflurane-induced hypotension

B. F. MATTA, MB, FRCA, A. M. LAM, MD, FRCPC, T. S. MAYBERG, MD, C. C. ENG, MD and S. STREBEL, MD

Department of Anesthesiology, University of Washington School of Medicine, Harborview Medical Center 325 Ninth Avenue, ZA-14, Seattle, WA 98104, USA

We have examined the cerebrovascular response to carbon dioxide during normotension, sodium nitroprusside (SNP)-induced hypotension and high dose isoflurane-induced hypotension in 10 patients who received a standardized general anaesthetic. Carbon dioxide reactivity was determined by varying Paco2 between 3.0 and 8.0 kPa and recording simultaneously blood flow velocity from the middle cerebral artery (vmca). The paired vmca-Paco2 data were analysed using linear regression to determine carbon dioxide reactivity. During hypotension, both high-dose isoflurane and SNP reduced significantly mean absolute (from 17.4 (SEM 2.3) to 13.0 (1.7) and 8.8 (1.3) cm s–1 kPa–1 respectively; P < 0.05) and relative (from 32.5 (3.8) to 23.6 (2.0) and 15.5 (1.3) % kPa– respectively; P < 0.05) cerebrovascular reactivity to carbon dioxide. This reduction was greater during SNP-induced hypotension (P < 0.05). We conclude that cerebrovascular reactivity to carbon dioxide was attenuated during isoflurane and SNP-induced hypotension, and that it was better preserved during isoflurane-induced hypotension. (Br. J. Anaesth. 1995; 74: 296–300)

Present addresses: Department of Anaesthesia, The Ipswich Hospital, Ipswich IP4 5PD, UK.

Present addresses: Phoenix Anesthesia Group, 2950 North 7th St, Phoenix, AZ 85014, USA.

Present addresses: University of Basel/Kantonsspital, Department of Anesthesia, CH-4031, Basel, Switzerland.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
Y. Kadoi, K.-i. Takahashi, S. Saito, and F. Goto
The comparative effects of sevoflurane versus isoflurane on cerebrovascular carbon dioxide reactivity in patients with diabetes mellitus.
Anesth. Analg., July 1, 2006; 103(1): 168 - 172.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
I. K. Moppett and R. P. Mahajan
Transcranial Doppler ultrasonography in anaesthesia and intensive care
Br. J. Anaesth., November 1, 2004; 93(5): 710 - 724.
[Full Text] [PDF]

Home page
 Anesth. Analg.Home page
H. Endoh, T. Honda, S. Ohashi, S. Hida, C. Shibue, and N. Komura
The Influence of Nicardipine-, Nitroglycerin-, and Prostaglandin E1-Induced Hypotension on Cerebral Pressure Autoregulation in Adult Patients During Propofol-Fentanyl Anesthesia
Anesth. Analg., January 1, 2002; 94(1): 169 - 173.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
H. Endoh, T. Honda, N. Komura, C. Shibue, I. Watanabe, and K. Shimoji
The Effects of Nicardipine on Dynamic Cerebral Autoregulation in Patients Anesthetized with Propofol and Fentanyl
Anesth. Analg., September 1, 2000; 91(3): 642 - 646.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.