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British Journal of Anaesthesia, 1994, Vol. 73, No. 4 490-493
© 1994 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

Pharmacodynamics of mivacurium in infants

O. A. MERETOJA, MD, PHD, T. TAIVAINEN, MD, PHD and K. WIRTAVUORI, MD

Department of Anaesthesiology, Children's Hospital University of Helsinki FIN-00290 Helsinki, Finland

Correspondence to O.A.M.

A computerized infusion system was used to determine mivacurium infusion requirements to maintain 95% and 50% neuromuscular block in 15 infants less than 1 yr of age. Neuromuscular block was measured by adductor pollicis EMG and anaesthesia maintained with 66% nitrous oxide in oxygen and alfentanil 50–100 µg kg–1 h–1. Neuromuscular block was produced by repeated bolus doses of mivacurium 0.1 mg kg–1; subsequently the target neuromuscular block was maintained by a closed loop infusion. Dose potency of mivacurium was similar to that previously published in children with a similar anaesthetic technique. Mean mivacurium requirement for 95% neuromuscular block was 820 (SD 300) µg kg–1 h–1, which represented an hourly requirement of 6.6 (1.5) individual ED95 doses. Infusion requirement for 50% neuromuscular block was 320 (150) µg kg–1 h–1. These infusion rates were similar to those in children. No side effects of mivacurium were noticed.


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