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British Journal of Anaesthesia, 1994, Vol. 73, No. 4 458-463
© 1994 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

Effect of ventilation on first-pass pulmonary retention of alfentanil and sufentanil in patients undergoing coronary artery surgery

F. BOER, MD, J. G. BOVILL, MD, PHD, FFARCSI, A. G. L. BURM, PHD and A. HAK, BSC

Department of Anaesthesiology, University Hospital Leiden Postbox 9600, 2300 RC Leiden, The Netherlands

We have studied, in 14 patients undergoing elective aorto—coronary bypass surgery, the effect of the type of ventilation on pulmonary retention of alfentanil and sufentanil using a double indicator technique. Patients were allocated to one of two groups to receive either bolus doses of sufentanil 33.2 µg (n=6) or alfentanil 654 µg (n=8), mixed with indocyanine green. In each patient, pulmonary first-pass retention was studied during apnoea (during the 1-min study period), normoventilation and positive end-expiratory pressure (10 mm Hg) ventilation, the order of which was randomized. After sufentanil, mean (95% confidence interval) first-pass pulmonary retention was 50.9 (41.7–60.1)% during apnoea, 50.8 (42.9–58.8)% during normoventilation and 54.4 (43.7–65.0)% during positive end-expiratory pressure ventilation. After alfentanil, first-pass pulmonary retention was 18.7 (5.4–32.0)% during apnoea, 19.9 (8.3–31.5)% during normoventilation and 16.6 (5.6–27.6)% during positive end-expiratory pressure ventilation. First-pass pulmonary retention of alfentanil and sufentanil was not significantly affected by the type of ventilation.


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