Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by WULF, H.
Right arrow Articles by HERZIG, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by WULF, H.
Right arrow Articles by HERZIG, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 1994, Vol. 73, No. 3 364-370
© 1994 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

Functional interaction between local anaesthetics and calcium antagonists in guineapig myocardium: 2. Electrophysiological studies with bupivacaine and nifedipine{dagger}

H. WULF, MD, J. GÖDICKE, MD and S. HERZIG, MD

Department of Anaesthesiology and Intensive Care Medicine, Hospital of the Christian Albrechts University Arnold-Heller-Strasse 7, D 24105 Kiel, Germany
Department of Pharmacology, Hospital of the Christian Albrechts University Arnold-Heller-Strasse 7, D 24105 Kiel, Germany

Correspondence to H. W.

The negative inotropic effect of local anaesthetics is potentiated by several calcium antagonists in guineapig myocardium [1] Therefore, we studied which effects on cardiac ionic currents could be responsible for this interaction. Concentration- response curves for bupivacaine were studied in isolated guineapig atria and papillary muscles (slow action potentials). Effects on action potentials were assessed in the absence (n = 7 atria, n = 8 papillary muscles) or presence of nifedipine (8 x 10–8w mol litre–1 in n = 8 atria, 10–8 mol litre–1 in n = 8 papillary muscles). The effect on the Ca2+ current was assessed directly using the patch-clamp technique in guineapig ventricular myocytes. Bupivacaine reduced contractile force and upstroke velocity of atrial action potentials. Only the negative inotropic effect was potentiated in the presence of nifedipine. Force and upstroke velocity of slow action potentials were diminished by bupivacaine. Both variables were affected at significantly smaller concentrations of bupivacaine when given in combination with nifedipine. The Ca2+ current was reduced significantly by bupivacaine 5 x 10–5 mol litre–1 (mean –18 (SD 7)%, n = 9). Its effect was accentuated in the presence of nifedipine 10–5 mol litre–1 (–47 (4)%, n = 7).Bupivacaine 3 x 10–4 mol litre–1 given alone exerted a comparable effect (–53 (4)%, n = 4). Variables indicative of Ca2+ channel function (contractile force, upstroke of slow but not normal action potentials, Ca2+ inward current) revealed potentiation of the effects of bupivacaine by nifedipine.

{dagger}Presented in part at the 1993 Annual Scientific Meeting of the German Society of Anaesthesiology and Intensive Care Medicine, Würzburg, Germany, and at the 1993 Spring Meeting of the German Society of Pharmacology and Toxicology, Mainz, Germany.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.