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British Journal of Anaesthesia, 1994, Vol. 73, No. 3 315-317
© 1994 The Board of Management and Trustees of the British Journal of Anaesthesia


research-article

Effect of four i.v. induction agents on T-lymphocyte proliferations to PHA in vitro

E. G. DEVLIN, MB, FFARCSI, R. S. J. CLARKE, MD, PHD, FRCA, FFARCSI, R. K. MIRAKHUR, MD, PHD, FRCA and T. A. MCNEILL, DSC, MD, FRCPATH

University Department of Anaesthetics, The Queen's University Belfast BT7 1NN, N. Ireland
University Department of Immunology, The Queen's University Belfast BT7 1NN, N. Ireland

Correspondence to E. G. D.

Anaesthetic agents are believed to have an adverse effect on human immunity. We have studied the effects of four i.v. induction agents, thiopentone, methohexitone, etomidate and propofol, on T-lymphocyte proliferations to phytohaemagglutinin in vitro. We found that at plasma concentrations similar to those obtained after induction doses, all drugs, with the exception of propofol, caused depression of T-lymphocyte function.


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