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British Journal of Anaesthesia, 1994, Vol. 72, No. 6 624-628
© 1994 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

Comparison of the analgesic and emetic properties of ketorolac and morphine for paediatric outpatient strabismus surgery

H. M. MUNRO, F.R.C.A., L. Q. RIEGGER, M.D., P. I. REYNOLDS, M.D., N. C. T. WILTON, M.R.C.P., F.R.C.A. and I. H. LEWIS, M.R.C.P., F.R.C.A.

Section of Pediatric Anesthesiology, C.S.Mott Children's Hospital, University of Michigan Room 4139, Box 0800, Ann Arbor, Michigan 48109, U.S.A.
*Shackleton Department of Anaesthetics, Southampton General Hospital Tremona Road, Southampton, Hants SO9 4XY
{dagger}Department of Anesthesiology, University of California Medical Center San Diego, California 92103, U.S.A.

Correspondence to H.M.M.

In a prospective, double-blind, randomized study, we have compared i.v. ketorolac and morphine in paediatric outpatients undergoing strabismus surgery. Forty-two ASA I or II children, aged 2–12 yr, were allocated randomly to receive either ketorolac 0.75mg kg–1 i.v. or morphine 0.1 mg kg–1i.v. and metoclopramide 0.15 mg kg–1. Anaesthesia was induced with propofol and maintained with propofol and nitrous oxide. Pain was assessed at 15-min intervals until discharge, and the incidence of nausea and vomiting was recorded for the first 24 h. There was no difference in pain behaviour scores or recovery times. The incidence of nausea and vomiting during the first 24 h was 19%in the ketorolac group and 71%in the morphine group (P<0.001). We concluded that ketorolac was an effective analgesic for this type of surgery and that it was associated with less postoperative emesis than morphine and metoclopramide.


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