Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (15)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by McCRIRRICK, A.
Right arrow Articles by MONK, C. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McCRIRRICK, A.
Right arrow Articles by MONK, C. R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 1994, Vol. 72, No. 5 529-532
© 1994 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

Comparison of i.v. and intra-tracheal administration of adrenaline

A. McCRIRRICK, F.R.C.A. and C. R. MONK, F.R.C.A.

Sir Humphry Davy Department of Anaesthesia, Bristol Royal Infirmary Bristol BS2 8HW

Correspondence to A. McC.

Adrenaline is the single most important therapeutic agent used in advanced cardiac life support (ACLS). Ideally it should be given into a large central vein but the European Resuscitation Council, the American Heart Association and the Resuscitation Council (U.K.) advise that adrenaline may be given into the trachea if i.v. access is not available. We have studied the effects of intra-tracheal and i.v. adrenaline in 16 patients undergoing mechanical ventilation. Log dose-response curves were constructed for systolic arterial pressure and heart rate responses. Intra-tracheal doses of adrenaline up to 10µg kg–1, approximately one-third of that recommended for resuscitation, had no effect on arterial pressure or heart rate, whereas adrenaline 0.1 µg kg–1 i.v. produced a mean increase in systolic pressure of 24 mm Hg. The intra-tracheal doses recommended for resuscitation (2–3 mg) are likely to be ineffective and consideration should be given to abandoning the tracheal route for adrenaline in ACLS. (Br. J. Anaesth. 1994; 72: 529–532)


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
Y. Manisterski, Z. Vaknin, R. Ben-Abraham, O. Efrati, D. Lotan, M. Berkovitch, A. Barak, Z. Barzilay, and G. Paret
Endotracheal Epinephrine: A Call for Larger Doses
Anesth. Analg., October 1, 2002; 95(4): 1037 - 1041.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
Z. Vaknin, Y. Manisterski, R. Ben-Abraham, O. Efrati, D. Lotan, Z. Barzilay, and G. Paret
Is Endotracheal Adrenaline Deleterious Because of the Beta Adrenergic Effect?
Anesth. Analg., June 1, 2001; 92(6): 1408 - 1412.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
K. Naganobu, Y. Hasebe, Y. Uchiyama, M. Hagio, and H. Ogawa
A Comparison of Distilled Water and Normal Saline as Diluents for Endobronchial Administration of Epinephrine in the Dog
Anesth. Analg., August 1, 2000; 91(2): 317 - 321.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
K. Raymondos, B. Panning, M. Leuwer, G. Brechelt, T. Korte, M. Niehaus, J. Tebbenjohanns, and S. Piepenbrock
Absorption and Hemodynamic Effects of Airway Administration of Adrenaline in Patients with Severe Cardiac Disease
Ann Intern Med, May 16, 2000; 132(10): 800 - 803.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.