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British Journal of Anaesthesia, 1993, Vol. 71, No. 6 873-876
© 1993 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

ISOFLURANE INHIBITS INSULIN SECRETION FROM ISOLATED RAT PANCREATIC ISLETS OF LANGERHANS{dagger}

J. P. DESBOROUGH, M.B., CH.B., F.R.C.A., P. M. JONES, PH.D, S. J. PERSAUD, M.B., B.S., F.F.R.C.A., M. J. LANDON, PH.D. and S. L. HOWELL, PH.D., D.SC.

Department of Anaesthesia, Royal Postgraduate Medical School, Hammersmith Hospital Du Cane Road, London W12 0HS
Biomedical Sciences Division, King's College Campden Hill Road, Kensington, London W8 7AH
Division of Anaesthesia, Clinical Research Centre Harrow, Middlesex, HA1 3UJ

*Present address, for correspondence: Department of Anaesthesia, St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE

We have investigated the effects of isoflurane on insulin secretion in vitro from rat isolated islets of Langerhans and found a significant, dose-related and reversible inhibition of insulin secretion. Isoflurane 2% decreased insulin secretion stimulated by glucose 20 mmol litre–1 to basal, nonstimulated values. In other studies to identify the stage in the stimulus secretion pathway for insulin at which the anaesthetic may exert an inhibitory action, we have stimulated insulin release using glyceraldehyde and a phorbol ester. Insulin se cretion induced by these secretagogues was also blocked by isofiurane. This suggests that the inhibitory effect of the anaesthetic agent may be at a site distal to stimulation of insulin secretion by glyceraldehyde and phorbol esters. (Br. J. Anaesth. 1993; 71: 873–876)

{dagger}Presented in part at the Anaesthetic Research Society, Leicester, July 1992 (British Journal of Anaesthesia 1992; 69: 352P).


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