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British Journal of Anaesthesia, 1993, Vol. 71, No. 6 869-872
© 1993 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

COMPARISON OF THE HAEMODYNAMIC EFFECTS OF ENOXIMONE AND PIROXIMONE IN PATIENTS AFTER CARDIAC SURGERY

A. PATEL, M.B., B.S., F.R.C.A., L. D. CALDICOTT, M.B., B.S., F.R.C.A., J. R. SKOYLES, M.B., B.S., F.F.R.C.A., P. DAS, M.B., B.S., F.R.C.A. and K. M. SHERRY, M.B., B.S., F.R.C.A.

Department of Anaesthetics, Northern General Hospital Herries Road, Sheffield S5 7AU
Department of Anaesthetics, Leeds General Infirmary Leeds
Department of Anaesthetics, Leicester Royal Infirmary Leicester LE1 5WW

Correspondence to K.M.S.

We have compared the haemodynamic effects of the imidazole derivative phosphodiesterase inhibitors enoximone and piroximone in patients with low cardiac output after cardiac surgery. Ten patients (group E) received enoximone and 10 patients (group P) received piroximone, both at a loading dose of 0.5 mg kg–1 followed by an infusion of 5 µg kg–1 min–1. In both groups the main changes with time were increases in cardiac index (maximum 24.5% in group E, 25.8% in group P) and decreases in systemic vascular resistance (maxi mum 26.8% in group E and 24.8% in group P). There were moderate increases in heart rate (maximum 11.3% in group E and 13% in group P) but a greater percentage decrease in mean arterial pressure in group E (maximum 11.9% vs 7.9%) with time. One patient in group E developed hypertension during the loading dose. Two patients in group E and two in group P developed hypotension during the loading dose. One patient in group E developed ventricular extras ystoles which may have been related to the drug being studied. (Br. J. Anaesth. 1993; 71: 869–872)


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