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British Journal of Anaesthesia, 1993, Vol. 71, No. 6 845-848
© 1993 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

ANTIEMETIC EFFICACY OF PROPHYLACTIC ONDANSETRON IN LAPAROSCOPIC SURGERY: RANDOMIZED, DOUBLE-BLIND COMPARISON WITH METOCLOPRAMIDE

J. H. RAPHAEL, F.R.C.A. and A. C. NORTON, B.SC., F.R.C.A.

Department of Anaesthetics, Pilgrim Hospital Boston, Lincolnshire PE21 9QS

In a randomized, double-blind study, we have compared the prophylactic antiemetic efficacy of ondansetron with that of metoclopramide in 123 patients undergoing general anaesthesia for day case gynaecological laparoscopic surgery. The patients received either i.v. ondansetron 4 mg or metoclopramide 10 mg immediately before a standard anaesthetic. The number of patients with no nausea or vomiting in the ondansteron group was 50 (82%) compared with 29 (47%) in the meto clopramide group (P<0.00 1). In those patients with a previous history of postoperative nausea and vomiting, nausea was less severe in those receiving ondansetron compared with those receiving meto clopramide (P<0.05). We conclude that pre operative prophylactic administration of i.v. ondan setron was superior to metoclopramide in pre venting nausea and vomiting after general an aesthesia for day-case gynaecological laparoscopic surgery. (Br. J. Anaesth. 1993; 71: 845–848)


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