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British Journal of Anaesthesia, 1993, Vol. 71, No. 6 839-844
© 1993 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

EFFECTS OF SMALL CONCENTRATIONS OF ISOFLURANE ON SOME PSYCHOMETRIC MEASUREMENTS

J. YOSHIZUMI, M.B., B.S., R. W. MARSHALL, B.SC.(HONS), L. D. SANDERS, PH.D., C.PSYCHOL., A.F.B.PS.S. and M. D. VICKERS, M.B., B.S., F.R.C.A.

Department of Anaesthetics, University of Wales College of Medicine Heath Park, Cardiff CF4 4XN
Department of Pharmacology and Therapeutics, University of Wales College of Medicine Heath Park, Cardiff CF4 4XN
Psychology Secnon, Cardiff Institute of Higher Education Llandaff Centre, Western Avenue, Cardiff CF5 2YB

Correspondence to M.D.V.

We have investigated the effects of 9.5% and 14.1% MAC concentrations of isoflurane on some psycho metric measurements. Both concentrations de pressed peak saccadic velocity (P<0.01), choice reaction time (P<0.05) and visual analogue scores for sedation (P<0.05), but not the critical flicker fusion threshold. The incidence of errors in saccade tasks increased in a dose-related fashion, which made analysis of peak saccadic velocity less ac curate at more than 10% MAC. The percentage error itseff was an indicator of the depth of sedation. All the objective measures correlated highly with the estimated brain tension of isoflurane (r2=0.86–0.96), but not the visual analogue score for sedation (r2=0.51). This suggests that a com bination of peak saccadic velocity, percentage error and choice reaction time is a potentially useful batch of tests to measure recovery from anaesthesia. (Br. J. Anaesth. 1993; 71: 839–844)


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