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British Journal of Anaesthesia, 1993, Vol. 71, No. 6 823-826
© 1993 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

PHARMACOKINETICS OF I.V. AND RECTAL PETHIDINE IN CHILDREN UNDERGOING OPHTHALMIC SURGERY

K. HAMUNEN, M.D., E.-L. MAUNUKSELA, M.D., PH.D., T. SEPPÄLÄ, M.D., PH.D. and K. T. OLKKOLA, M.D., PH.D.

Departments of Ophthalmology and Anaesthesia, University of Helsinki and Department of Pharmacology and Toxicology, National Public Health Institute Helsinki, SF-00290, Finland

*Address for correspondence: Department of Ophthalmology, Helsinki University Hospital, Haartmaninkatu 4 C, SF-00290 Helsinki, Finland

We have studied the pharmacokinetics of i.v. and rectal pethidine in 20 children age 4–8 yr under going ophthalmic surgery. After i.v. administration, the clearance of pethidine was mean 10.4 (SD 1.7) ml kg–1 min–1, volume of distribution at steady state 2.8 (0.6) litre kg–1 and elimination haff-ilfe 3.0 (0.5) h. After rectal administration, plasma pethidine concentrations varied greatly and peak concentrations appeared late, at 147 (44) mm. The mean systemic bioavailabiity after rectal admin istration was approximately 55%. Because the bioavailabiity of rectal pethidine varies greatly, this route is not encouraged in the management of acute pain. (Br. J. Anaesth. 1993; 71: 823–826)


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