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British Journal of Anaesthesia, 1993, Vol. 71, No. 6 814-817
© 1993 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

ORAL BROMFENAC 10 AND 25 MG COMPARED WITH SUBLINGUAL BUPRENORPHINE 0.2 AND 0.4 MG FOR POSTOPERATIVE PAIN RELIEF

D. CARROLL, R.G.N., T. FRANKLAND, R.G.N., C. NAGLE, M.B., B.CH., F.R.C.A. and H. MCQUAY, D.M., F.R.C.A.

Oxford Regional Pain Relief Unit, Churchill Hospital, Oxford & Nuffield Department of Anaesthetics, University of, Oxford

The aim of this single-dose, randomized, positive control, double-dummy, double-blind, parallel group study was to compare oral bromfenac 10 and 25 mg with sublingual buprenorphine 0.2 and 0.4 mg for treatment of postoperative pain. We studied 91 patients with moderate or severe pain after general surgical or orthopaedic operations, using pain intensity, pain relief, adverse effect, mood and sedation outcomes. There was a sig nificant analgesic dose—response for buprenor phine, showing study sensitivity, but not for bromfenac. The two bromfenac treatments were significantly superior to the two buprenorphine treatments. Significantly more patients reported nausea with buprenorphine. There was evidence of a ceiling effect for analgesia with bromfenac. (Br. J. Anaesth. 1993; 71: 814–817)

*Address for correspondence: Oxford Regional Pain Relief Unit, Churchill Hospital, Oxford OX3 7LJ.


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